1: Ji Z, Tang Q, Zhang J, Yang Y, Liu Y, Pan YJ. Immunomodulation of Bone Marrow Macrophages by GLIS, a Proteoglycan Fraction from Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidium (W.Curt.:Fr.) P. Karst. Int J Med Mushrooms. 2011;13(5):441-8. PubMed PMID: 22324409. 2: Hanaoka R, Ueno Y, Tanaka S, Nagai K, Onitake T, Yoshioka K, Chayama K. The water-soluble extract from cultured medium of Ganoderma lucidum (Reishi) mycelia (Designated as MAK) ameliorates murine colitis induced by trinitrobenzene sulphonic acid. Scand J Immunol. 2011 Nov;74(5):454-62. doi: 10.1111/j.1365-3083.2011.02601.x. PubMed PMID: 21973321. 3: Smina TP, De S, Devasagayam TP, Adhikari S, Janardhanan KK. Ganoderma lucidum total triterpenes prevent radiation-induced DNA damage and apoptosis in splenic lymphocytes in vitro. Mutat Res. 2011 Dec 24;726(2):188-94. Epub 2011 Sep 16. PubMed PMID: 21944902. 4: Meng J, Hu X, Shan F, Hua H, Lu C, Wang E, Liang Z. Analysis of maturation of murine dendritic cells (DCs) induced by purified Ganoderma lucidum polysaccharides (GLPs). Int J Biol Macromol. 2011 Nov 1;49(4):693-9. Epub 2011 Jul 7. PubMed PMID: 21763719. 5: Jan RH, Lin TY, Hsu YC, Lee SS, Lo SY, Chang M, Chen LK, Lin YL. Immuno-modulatory activity of Ganoderma lucidum-derived polysacharide on human monocytoid dendritic cells pulsed with Der p 1 allergen. BMC Immunol. 2011 May 25;12:31. PubMed PMID: 21612588; PubMed Central PMCID: PMC3127845. 6: Lin CC, Yu YL, Shih CC, Liu KJ, Ou KL, Hong LZ, Chen JD, Chu CL. A novel adjuvant Ling Zhi-8 enhances the efficacy of DNA cancer vaccine by activating dendritic cells. Cancer Immunol Immunother. 2011 Jul;60(7):1019-27. Epub 2011 Apr 17. PubMed PMID: 21499904. 7: Sun LX, Lin ZB, Duan XS, Lu J, Ge ZH, Li XJ, Li M, Xing EH, Jia J, Lan TF, Li WD. Ganoderma lucidum polysaccharides antagonize the suppression on lymphocytes induced by culture supernatants of B16F10 melanoma cells. J Pharm Pharmacol. 2011 May;63(5):725-35. doi: 10.1111/j.2042-7158.2011.01266.x. PubMed PMID: 21492175. 8: Watanabe K, Shuto T, Sato M, Onuki K, Mizunoe S, Suzuki S, Sato T, Koga T, Suico MA, Kai H, Ikeda T. Lucidenic acids-rich extract from antlered form of Ganoderma lucidum enhances TNFα induction in THP-1 monocytic cells possibly via its modulation of MAP kinases p38 and JNK. Biochem Biophys Res Commun. 2011 Apr 29;408(1):18-24. Epub 2011 Mar 29. PubMed PMID: 21453678. 9: An M, Gao GF, Qi J, Li F, Liu X. [Expression and crystallographic studies of a fungal immunomodulatory protein LZ-8 from a medicinal fungus Ganoderma lucidum]. Sheng Wu Gong Cheng Xue Bao. 2010 Nov;26(11):1563-8. Chinese. PubMed PMID: 21284217. 10: Chen Y, Lu H, Song S, Jia X. [Preparation of Ganoderma lucidum polysaccharides and triterpenes microemulsion and its anticancer effect in mice with transplant Heps tumors]. Zhongguo Zhong Yao Za Zhi. 2010 Oct;35(20):2679-83. Chinese. PubMed PMID: 21246817. 11: Xu Z, Chen X, Zhong Z, Chen L, Wang Y. Ganoderma lucidum polysaccharides: immunomodulation and potential anti-tumor activities. Am J Chin Med. 2011;39(1):15-27. Review. PubMed PMID: 21213395. 12: Sun LX, Lin ZB, Li XJ, Li M, Lu J, Duan XS, Ge ZH, Song YX, Xing EH, Li WD. Promoting effects of Ganoderma lucidum polysaccharides on B16F10 cells to activate lymphocytes. Basic Clin Pharmacol Toxicol. 2011 Mar;108(3):149-54. doi: 10.1111/j.1742-7843.2010.00632.x. Epub 2010 Oct 22. PubMed PMID: 20964805. 13: Andoh T, Zhang Q, Yamamoto T, Tayama M, Hattori M, Tanaka K, Kuraishi Y. Inhibitory effects of the methanol extract of Ganoderma lucidum on mosquito allergy-induced itch-associated responses in mice. J Pharmacol Sci. 2010;114(3):292-7. Epub 2010 Oct 8. PubMed PMID: 20948166. 14: Zhang J, Tang Q, Zhou C, Jia W, Da Silva L, Nguyen LD, Reutter W, Fan H. GLIS, a bioactive proteoglycan fraction from Ganoderma lucidum, displays anti-tumour activity by increasing both humoral and cellular immune response. Life Sci. 2010 Nov 20;87(19-22):628-37. Epub 2010 Oct 1. PubMed PMID: 20888840. 15: Li N, Hu YL, He CX, Hu CJ, Zhou J, Tang GP, Gao JQ. Preparation, characterisation and anti-tumour activity of Ganoderma lucidum polysaccharide nanoparticles. J Pharm Pharmacol. 2010 Jan;62(1):139-44. PubMed PMID: 20723010. 16: Yeh CH, Chen HC, Yang JJ, Chuang WI, Sheu F. Polysaccharides PS-G and protein LZ-8 from Reishi (Ganoderma lucidum) exhibit diverse functions in regulating murine macrophages and T lymphocytes. J Agric Food Chem. 2010 Aug 11;58(15):8535-44. PubMed PMID: 20681640. 17: Huang SQ, Li JW, Wang Z, Pan HX, Chen JX, Ning ZX. Optimization of alkaline extraction of polysaccharides from Ganoderma lucidum and their effect on immune function in mice. Molecules. 2010 May 25;15(5):3694-708. PubMed PMID: 20657508. 18: Lai CY, Hung JT, Lin HH, Yu AL, Chen SH, Tsai YC, Shao LE, Yang WB, Yu J. Immunomodulatory and adjuvant activities of a polysaccharide extract of Ganoderma lucidum in vivo and in vitro. Vaccine. 2010 Jul 12;28(31):4945-54. PubMed PMID: 20653103. 19: Cheng CH, Leung AY, Chen CF. The effects of two different ganoderma species (Lingzhi) on gene expression in human monocytic THP-1 cells. Nutr Cancer. 2010;62(5):648-58. PubMed PMID: 20574926. 20: Price LA, Wenner CA, Sloper DT, Slaton JW, Novack JP. Role for toll-like receptor 4 in TNF-alpha secretion by murine macrophages in response to polysaccharide Krestin, a Trametes versicolor mushroom extract. Fitoterapia. 2010 Oct;81(7):914-9. Epub 2010 Jun 13. PubMed PMID: 20550956. 21: Lee SH, Lillehoj HS, Hong YH, Jang SI, Lillehoj EP, Ionescu C, Mazuranok L, Bravo D. In vitro effects of plant and mushroom extracts on immunological function of chicken lymphocytes and macrophages. Br Poult Sci. 2010 Apr;51(2):213-21. PubMed PMID: 20461582. 22: Huang SQ, Ning ZX. Extraction of polysaccharide from Ganoderma lucidum and its immune enhancement activity. Int J Biol Macromol. 2010 Oct 1;47(3):336-41. Epub 2010 Apr 4. PubMed PMID: 20371373. 23: Rubel R, Dalla Santa HS, Bonatto SJ, Bello S, Fernandes LC, Di Bernardi R, Gern J, Santos CA, Soccol CR. Medicinal mushroom Ganoderma lucidum (Leyss: Fr) Karst. triggers immunomodulatory effects and reduces nitric oxide synthesis in mice. J Med Food. 2010 Feb;13(1):142-8. PubMed PMID: 20136448. 24: Sze DM, Chan GC. Supplements for immune enhancement in hematologic malignancies. Hematology Am Soc Hematol Educ Program. 2009:313-9. Review. PubMed PMID: 20008216. 25: Chang YH, Yang JS, Yang JL, Wu CL, Chang SJ, Lu KW, Lin JJ, Hsia TC, Lin YT, Ho CC, Wood WG, Chung JG. Ganoderma lucidum extracts inhibited leukemia WEHI-3 cells in BALB/c mice and promoted an immune response in vivo. Biosci Biotechnol Biochem. 2009 Dec;73(12):2589-94. Epub 2009 Dec 7. PubMed PMID: 19966494. 26: Volman JJ, Helsper JP, Wei S, Baars JJ, van Griensven LJ, Sonnenberg AS, Mensink RP, Plat J. Effects of mushroom-derived beta-glucan-rich polysaccharide extracts on nitric oxide production by bone marrow-derived macrophages and nuclear factor-kappaB transactivation in Caco-2 reporter cells: can effects be explained by structure? Mol Nutr Food Res. 2010 Feb;54(2):268-76. PubMed PMID: 19885842. 27: Chang YH, Yang JS, Yang JL, Wu CL, Chang SJ, Lu KW, Kuo CL, Hsia TC, Chung JG. Gandoderma lucidum extract promotes immune responses in normal BALB/c mice In vivo. In Vivo. 2009 Sep-Oct;23(5):755-9. PubMed PMID: 19779111. 28: Zhao H, Luo Y, Lu C, Lin N, Xiao C, Guan S, Guo DA, Liu Z, Ju D, He X, Lu A. Enteric mucosal immune response might trigger the immunomodulation activity of Ganoderma lucidum polysaccharide in mice. Planta Med. 2010 Feb;76(3):223-7. Epub 2009 Aug 25. PubMed PMID: 19708002. 29: Liu J, Shiono J, Shimizu K, Kondo R. Ganoderic acids from Ganoderma lucidum: inhibitory activity of osteoclastic differentiation and structural criteria. Planta Med. 2010 Feb;76(2):137-9. Epub 2009 Aug 10. PubMed PMID: 19670160. 30: Dudhgaonkar S, Thyagarajan A, Sliva D. Suppression of the inflammatory response by triterpenes isolated from the mushroom Ganoderma lucidum. Int Immunopharmacol. 2009 Oct;9(11):1272-80. Epub 2009 Aug 3. PubMed PMID: 19651243. 31: Liang C, Zhang S, Liu Z, Sun F. Ganoderma lucidum immunomodulatory protein(Lz-8) expressed in Pichia pastoris and the identification of immunocompetence. Sheng Wu Gong Cheng Xue Bao. 2009 Mar;25(3):441-7. PubMed PMID: 19621588. 32: Ahmadi K, Riazipour M. Ganoderma lucidum induces the expression of CD40/CD86 on peripheral blood monocytes. Iran J Immunol. 2009 Jun;6(2):87-91. PubMed PMID: 19561377. 33: Guo L, Xie J, Ruan Y, Zhou L, Zhu H, Yun X, Jiang Y, Lü L, Chen K, Min Z, Wen Y, Gu J. Characterization and immunostimulatory activity of a polysaccharide from the spores of Ganoderma lucidum. Int Immunopharmacol. 2009 Sep;9(10):1175-82. Epub 2009 Jun 21. PubMed PMID: 19540939. 34: Zhou GQ, Zhao HY, Lu C. [Effect of Ganoderma lucidum polysaccharides on intestinal mucosal immune system in H22 liver cancer bearing mice]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Apr;29(4):335-9. Chinese. PubMed PMID: 19526760. 35: Lin YL, Liang YC, Tseng YS, Huang HY, Chou SY, Hseu RS, Huang CT, Chiang BL. An immunomodulatory protein, Ling Zhi-8, induced activation and maturation of human monocyte-derived dendritic cells by the NF-kappaB and MAPK pathways. J Leukoc Biol. 2009 Oct;86(4):877-89. Epub 2009 Jun 4. PubMed PMID: 19498044. 36: Ma C, Yue QX, Guan SH, Wu WY, Yang M, Jiang BH, Liu X, Guo DA. Proteomic analysis of possible target-related proteins of cyclophosphamide in mice thymus. Food Chem Toxicol. 2009 Aug;47(8):1841-7. Epub 2009 May 5. PubMed PMID: 19422872. 37: Qi G, Hua H, Gao Y, Lin Q, Yu GY. Effects of Ganoderma lucidum spores on sialoadenitis of nonobese diabetic mice. Chin Med J (Engl). 2009 Mar 5;122(5):556-60. PubMed PMID: 19323907. 38: Xue Q, Ding Y, Shang C, Jiang C, Zhao M. Functional expression of LZ-8, a fungal immunomodulatory protein from Ganoderma lucidium in Pichia pastoris. J Gen Appl Microbiol. 2008 Dec;54(6):393-8. PubMed PMID: 19164882. 39: Zhuang SR, Chen SL, Tsai JH, Huang CC, Wu TC, Liu WS, Tseng HC, Lee HS, Huang MC, Shane GT, Yang CH, Shen YC, Yan YY, Wang CK. Effect of citronellol and the Chinese medical herb complex on cellular immunity of cancer patients receiving chemotherapy/radiotherapy. Phytother Res. 2009 Jun;23(6):785-90. PubMed PMID: 19145638. 40: Driscoll M, Hansen R, Ding C, Cramer DE, Yan J. Therapeutic potential of various beta-glucan sources in conjunction with anti-tumor monoclonal antibody in cancer therapy. Cancer Biol Ther. 2009 Feb;8(3):218-25. Epub 2009 Feb 3. PubMed PMID: 19106638. 41: Miyamoto I, Liu J, Shimizu K, Sato M, Kukita A, Kukita T, Kondo R. Regulation of osteoclastogenesis by ganoderic acid DM isolated from Ganoderma lucidum. Eur J Pharmacol. 2009 Jan 5;602(1):1-7. Epub 2008 Nov 9. PubMed PMID: 19026632. 42: Fukuzawa M, Yamaguchi R, Hide I, Chen Z, Hirai Y, Sugimoto A, Yasuhara T, Nakata Y. Possible involvement of long chain fatty acids in the spores of Ganoderma lucidum (Reishi Houshi) to its anti-tumor activity. Biol Pharm Bull. 2008 Oct;31(10):1933-7. PubMed PMID: 18827358. 43: Ye L, Zhang J, Zhou K, Yang Y, Zhou S, Jia W, Hao R, Pan Y. Purification, NMR study and immunostimulating property of a fucogalactan from the fruiting bodies of Ganoderma lucidum. Planta Med. 2008 Nov;74(14):1730-4. Epub 2008 Aug 5. PubMed PMID: 18683124. 44: Chan WK, Cheung CC, Law HK, Lau YL, Chan GC. Ganoderma lucidum polysaccharides can induce human monocytic leukemia cells into dendritic cells with immuno-stimulatory function. J Hematol Oncol. 2008 Jul 21;1:9. PubMed PMID: 18644156; PubMed Central PMCID: PMC2517069. 45: Gill SK, Rieder MJ. Toxicity of a traditional Chinese medicine, Ganoderma lucidum, in children with cancer. Can J Clin Pharmacol. 2008 Summer;15(2):e275-85. Epub 2008 Jul 4. PubMed PMID: 18603664. 46: Yue GG, Fung KP, Leung PC, Lau CB. Comparative studies on the immunomodulatory and antitumor activities of the different parts of fruiting body of Ganoderma lucidum and Ganoderma spores. Phytother Res. 2008 Oct;22(10):1282-91. PubMed PMID: 18570198. 47: Jeurink PV, Noguera CL, Savelkoul HF, Wichers HJ. Immunomodulatory capacity of fungal proteins on the cytokine production of human peripheral blood mononuclear cells. Int Immunopharmacol. 2008 Aug;8(8):1124-33. Epub 2008 May 7. PubMed PMID: 18550017. 48: Nonaka Y, Ishibashi H, Nakai M, Shibata H, Kiso Y, Abe S. Effects of the antlered form of Ganoderma lucidum on tumor growth and metastasis in cyclophosphamide-treated mice. Biosci Biotechnol Biochem. 2008 Jun;72(6):1399-408. Epub 2008 Jun 7. PubMed PMID: 18540114. 49: Tong MH, Chien PJ, Chang HH, Tsai MJ, Sheu F. High processing tolerances of immunomodulatory proteins in Enoki and Reishi mushrooms. J Agric Food Chem. 2008 May 14;56(9):3160-6. Epub 2008 Apr 19. PubMed PMID: 18422333. 50: Ma C, Guan SH, Yang M, Liu X, Guo DA. Differential protein expression in mouse splenic mononuclear cells treated with polysaccharides from spores of Ganoderma lucidum. Phytomedicine. 2008 Apr;15(4):268-76. Epub 2008 Jan 28. PubMed PMID: 18222673. 51: Hsu HY, Hua KF, Wu WC, Hsu J, Weng ST, Lin TL, Liu CY, Hseu RS, Huang CT. Reishi immuno-modulation protein induces interleukin-2 expression via protein kinase-dependent signaling pathways within human T cells. J Cell Physiol. 2008 Apr;215(1):15-26. PubMed PMID: 18189229. 52: Ahmadi K, Riazipour M. Effect of Ganoderma lucidum on cytokine release by peritoneal macrophages. Iran J Immunol. 2007 Dec;4(4):220-6. PubMed PMID: 18057580. 53: Zhang Y, Lin Z, Hu Y, Wang F. Effect of Ganoderma lucidum capsules on T lymphocyte subsets in football players on "living high-training low". Br J Sports Med. 2008 Oct;42(10):819-22. Epub 2007 Nov 29. Erratum in: Br J Sports Med. 2009 Apr;43(4):310-1. PubMed PMID: 18048435. 54: Chen CF, Yang XT, Li XQ, Mi K, Yang QY. [A comparison study on the physical/chemical properties and immunomodulatory activities of mycelial polysaccharide extracts from five Ganoderma species]. Wei Sheng Wu Xue Bao. 2007 Aug;47(4):628-33. Chinese. PubMed PMID: 17944362. 55: Li EK, Tam LS, Wong CK, Li WC, Lam CW, Wachtel-Galor S, Benzie IF, Bao YX, Leung PC, Tomlinson B. Safety and efficacy of Ganoderma lucidum (lingzhi) and San Miao San supplementation in patients with rheumatoid arthritis: a double-blind, randomized, placebo-controlled pilot trial. Arthritis Rheum. 2007 Oct 15;57(7):1143-50. PubMed PMID: 17907228. 56: Zhou X, Lin J, Yin Y, Zhao J, Sun X, Tang K. Ganodermataceae: natural products and their related pharmacological functions. Am J Chin Med. 2007;35(4):559-74. Review. PubMed PMID: 17708623. 57: Ko HH, Hung CF, Wang JP, Lin CN. Antiinflammatory triterpenoids and steroids from Ganoderma lucidum and G. tsugae. Phytochemistry. 2008 Jan;69(1):234-9. Epub 2007 Jul 25. PubMed PMID: 17655889. 58: Chan WK, Law HK, Lin ZB, Lau YL, Chan GC. Response of human dendritic cells to different immunomodulatory polysaccharides derived from mushroom and barley. Int Immunol. 2007 Jul;19(7):891-9. Epub 2007 Jul 2. PubMed PMID: 17606977. 59: Ji Z, Tang Q, Zhang J, Yang Y, Jia W, Pan Y. Immunomodulation of RAW264.7 macrophages by GLIS, a proteopolysaccharide from Ganoderma lucidum. J Ethnopharmacol. 2007 Jul 25;112(3):445-50. Epub 2007 Apr 8. PubMed PMID: 17524580. 60: Cheuk W, Chan JK, Nuovo G, Chan MK, Fok M. Regression of gastric large B-Cell lymphoma accompanied by a florid lymphoma-like T-cell reaction: immunomodulatory effect of Ganoderma lucidum (Lingzhi)? Int J Surg Pathol. 2007 Apr;15(2):180-6. PubMed PMID: 17478779. 61: Hua KF, Hsu HY, Chao LK, Chen ST, Yang WB, Hsu J, Wong CH. Ganoderma lucidum polysaccharides enhance CD14 endocytosis of LPS and promote TLR4 signal transduction of cytokine expression. J Cell Physiol. 2007 Aug;212(2):537-50. PubMed PMID: 17474083. 62: Wang G, Zhao J, Liu J, Huang Y, Zhong JJ, Tang W. Enhancement of IL-2 and IFN-gamma expression and NK cells activity involved in the anti-tumor effect of ganoderic acid Me in vivo. Int Immunopharmacol. 2007 Jun;7(6):864-70. Epub 2007 Mar 13. PubMed PMID: 17466920. 63: Zhu XL, Chen AF, Lin ZB. Ganoderma lucidum polysaccharides enhance the function of immunological effector cells in immunosuppressed mice. J Ethnopharmacol. 2007 May 4;111(2):219-26. Epub 2006 Nov 21. PubMed PMID: 17182202. 64: Nonaka Y, Shibata H, Nakai M, Kurihara H, Ishibashi H, Kiso Y, Tanaka T, Yamaguchi H, Abe S. Anti-tumor activities of the antlered form of Ganoderma lucidum in allogeneic and syngeneic tumor-bearing mice. Biosci Biotechnol Biochem. 2006 Sep;70(9):2028-34. Epub 2006 Sep 7. PubMed PMID: 16960396. 65: Xi Bao Y, Kwok Wong C, Kwok Ming Li E, Shan Tam L, Chung Leung P, Bing Yin Y, Wai Kei Lam C. Immunomodulatory effects of lingzhi and san-miao-san supplementation on patients with rheumatoid arthritis. Immunopharmacol Immunotoxicol. 2006;28(2):197-200. PubMed PMID: 16873089. 66: Lin KI, Kao YY, Kuo HK, Yang WB, Chou A, Lin HH, Yu AL, Wong CH. Reishi polysaccharides induce immunoglobulin production through the TLR4/TLR2-mediated induction of transcription factor Blimp-1. J Biol Chem. 2006 Aug 25;281(34):24111-23. Epub 2006 Jun 23. PubMed PMID: 16798741. 67: Zhang Q, Lei LS, Zhu ZG, Yu CL, Wu SG. [Ganoderma polysaccharides antagonize prostaglandin E2-induced suppression of murine splenocyte IFN-gamma and TNF-alpha mRNA expression]. Nan Fang Yi Ke Da Xue Xue Bao. 2006 Jun;26(6):780-3. Chinese. PubMed PMID: 16793600. 68: Lin YL, Lee SS, Hou SM, Chiang BL. Polysaccharide purified from Ganoderma lucidum induces gene expression changes in human dendritic cells and promotes T helper 1 immune response in BALB/c mice. Mol Pharmacol. 2006 Aug;70(2):637-44. Epub 2006 May 2. PubMed PMID: 16670374. 69: Chen X, Hu ZP, Yang XX, Huang M, Gao Y, Tang W, Chan SY, Dai X, Ye J, Ho PC, Duan W, Yang HY, Zhu YZ, Zhou SF. Monitoring of immune responses to a herbal immuno-modulator in patients with advanced colorectal cancer. Int Immunopharmacol. 2006 Mar;6(3):499-508. Epub 2005 Sep 15. PubMed PMID: 16428086. 70: Chan WK, Lam DT, Law HK, Wong WT, Koo MW, Lau AS, Lau YL, Chan GC. Ganoderma lucidum mycelium and spore extracts as natural adjuvants for immunotherapy. J Altern Complement Med. 2005 Dec;11(6):1047-57. PubMed PMID: 16398597. 71: Wang PY, Wang SZ, Lin SQ, Lin ZB. [Comparison of the immunomodulatory effects of spore polysaccharides and broken spore polysaccharides isolated from Ganoderma lucidum on murine splenic lymphocytes and peritoneal macrophages in vitro]. Beijing Da Xue Xue Bao. 2005 Dec 18;37(6):569-74. Chinese. PubMed PMID: 16378103. 72: Woo CW, Man RY, Siow YL, Choy PC, Wan EW, Lau CS, O K. Ganoderma lucidum inhibits inducible nitric oxide synthase expression in macrophages. Mol Cell Biochem. 2005 Jul;275(1-2):165-71. PubMed PMID: 16335796. 73: Nonaka Y, Ishibashi H, Nakai M, Shibata H, Kiso Y, Abe S. [Soothing effect of Ganoderma lucidum antlered form on cyclophosphamide-induced adverse reaction]. Gan To Kagaku Ryoho. 2005 Oct;32(11):1586-8. Japanese. PubMed PMID: 16315878. 74: Yang XF, Huang Q, Huang JM, Li Z, Cai M, Huang JK, Chen BF. [Application of flow cytometry on functional assessment of health food]. Zhonghua Yu Fang Yi Xue Za Zhi. 2005 Sep;39(5):335-41. Chinese. PubMed PMID: 16266546. 75: Lin ZB. Cellular and molecular mechanisms of immuno-modulation by Ganoderma lucidum. J Pharmacol Sci. 2005 Oct;99(2):144-53. Review. PubMed PMID: 16230843. 76: Kuo MC, Weng CY, Ha CL, Wu MJ. Ganoderma lucidum mycelia enhance innate immunity by activating NF-kappaB. J Ethnopharmacol. 2006 Jan 16;103(2):217-22. Epub 2005 Sep 15. PubMed PMID: 16169168. 77: Wachtel-Galor S, Choi SW, Benzie IF. Effect of Ganoderma lucidum on human DNA is dose dependent and mediated by hydrogen peroxide. Redox Rep. 2005;10(3):145-9. PubMed PMID: 16156953. 78: Gao Y, Tang W, Dai X, Gao H, Chen G, Ye J, Chan E, Koh HL, Li X, Zhou S. Effects of water-soluble Ganoderma lucidum polysaccharides on the immune functions of patients with advanced lung cancer. J Med Food. 2005 Summer;8(2):159-68. PubMed PMID: 16117607. 79: Zhu XL, Lin ZB. Effects of Ganoderma lucidum polysaccharides on proliferation and cytotoxicity of cytokine-induced killer cells. Acta Pharmacol Sin. 2005 Sep;26(9):1130-7. PubMed PMID: 16115382. 80: Jiang Y, Wang H, Lü L, Tian GY. [Chemistry of polysaccharide Lzps-1 from Ganoderma lucidum spore and anti-tumor activity of its total polysaccharides]. Yao Xue Xue Bao. 2005 Apr;40(4):347-50. Chinese. PubMed PMID: 16011264. 81: Gao Y, Gao H, Chan E, Tang W, Xu A, Yang H, Huang M, Lan J, Li X, Duan W, Xu C, Zhou S. Antitumor activity and underlying mechanisms of ganopoly, the refined polysaccharides extracted from Ganoderma lucidum, in mice. Immunol Invest. 2005;34(2):171-98. PubMed PMID: 15921158. 82: Lin YL, Liang YC, Lee SS, Chiang BL. Polysaccharide purified from Ganoderma lucidum induced activation and maturation of human monocyte-derived dendritic cells by the NF-kappaB and p38 mitogen-activated protein kinase pathways. J Leukoc Biol. 2005 Aug;78(2):533-43. Epub 2005 May 13. PubMed PMID: 15894585. 83: Lai SW, Lin JH, Lai SS, Wu YL. Influence of Ganoderma lucidum on blood biochemistry and immunocompetence in horses. Am J Chin Med. 2004;32(6):931-40. PubMed PMID: 15673198. 84: Zhang W, Zeng YS. [Progress in research on Ganoderma lucidium spore]. Zhong Xi Yi Jie He Xue Bao. 2004 Nov;2(6):463-5. Review. Chinese. PubMed PMID: 15539032. 85: Hsu HY, Hua KF, Lin CC, Lin CH, Hsu J, Wong CH. Extract of Reishi polysaccharides induces cytokine expression via TLR4-modulated protein kinase signaling pathways. J Immunol. 2004 Nov 15;173(10):5989-99. PubMed PMID: 15528333. 86: Lin ZB, Zhang HN. Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms. Acta Pharmacol Sin. 2004 Nov;25(11):1387-95. Review. PubMed PMID: 15525457. 87: Chien CM, Cheng JL, Chang WT, Tien MH, Tsao CM, Chang YH, Chang HY, Hsieh JF, Wong CH, Chen ST. Polysaccharides of Ganoderma lucidum alter cell immunophenotypic expression and enhance CD56+ NK-cell cytotoxicity in cord blood. Bioorg Med Chem. 2004 Nov 1;12(21):5603-9. PubMed PMID: 15465338. 88: Chen HS, Tsai YF, Lin S, Lin CC, Khoo KH, Lin CH, Wong CH. Studies on the immuno-modulating and anti-tumor activities of Ganoderma lucidum (Reishi) polysaccharides. Bioorg Med Chem. 2004 Nov 1;12(21):5595-601. PubMed PMID: 15465337. 89: Shao BM, Dai H, Xu W, Lin ZB, Gao XM. Immune receptors for polysaccharides from Ganoderma lucidum. Biochem Biophys Res Commun. 2004 Oct 8;323(1):133-41. PubMed PMID: 15351712. 90: Tang QJ, Zhang JS, Pan YJ, Reutter W, Fan H. [Activation of mouse macrophages by the alkali-extracted polysaccharide from spore of Ganoderma lucidum]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2004 Mar;20(2):142-4. Chinese. PubMed PMID: 15191711. 91: Tan BK, Vanitha J. Immunomodulatory and antimicrobial effects of some traditional chinese medicinal herbs: a review. Curr Med Chem. 2004 Jun;11(11):1423-30. Review. PubMed PMID: 15180575. 92: Cao QZ, Lin ZB. Antitumor and anti-angiogenic activity of Ganoderma lucidum polysaccharides peptide. Acta Pharmacol Sin. 2004 Jun;25(6):833-8. PubMed PMID: 15169641. 93: Kohguchi M, Kunikata T, Watanabe H, Kudo N, Shibuya T, Ishihara T, Iwaki K, Ikeda M, Fukuda S, Kurimoto M. Immuno-potentiating effects of the antler-shaped fruiting body of Ganoderma lucidum (Rokkaku-Reishi). Biosci Biotechnol Biochem. 2004 Apr;68(4):881-7. PubMed PMID: 15118318. 94: Wachtel-Galor S, Tomlinson B, Benzie IF. Ganoderma lucidum ("Lingzhi"), a Chinese medicinal mushroom: biomarker responses in a controlled human supplementation study. Br J Nutr. 2004 Feb;91(2):263-9. PubMed PMID: 14756912. 95: Liu YH, Tsai CF, Kao MC, Lai YL, Tsai JJ. Effectiveness of Dp2 nasal therapy for Dp2- induced airway inflammation in mice: using oral Ganoderma lucidum as an immunomodulator. J Microbiol Immunol Infect. 2003 Dec;36(4):236-42. PubMed PMID: 14723251. 96: Chien CM, Cheng JL, Chang WT, Tien MH, Wu WY, Chang YH, Chang HY, Chen ST. Cell phenotype analysis using a cell fluid-based microchip with high sensitivity and accurate quantitation. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Sep 25;795(1):1-8. PubMed PMID: 12957163. 97: Gao Y, Zhou S, Jiang W, Huang M, Dai X. Effects of ganopoly (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients. Immunol Invest. 2003 Aug;32(3):201-15. PubMed PMID: 12916709. 98: Cao LZ, Lin ZB. Comparison of the effects of polysaccharides from wood-cultured and bag-cultured Ganoderma lucidum on murine spleen lymphocyte proliferation in vitro. Yao Xue Xue Bao. 2003 Feb;38(2):92-7. PubMed PMID: 12778741. 99: Hsu MJ, Lee SS, Lee ST, Lin WW. Signaling mechanisms of enhanced neutrophil phagocytosis and chemotaxis by the polysaccharide purified from Ganoderma lucidum. Br J Pharmacol. 2003 May;139(2):289-98. PubMed PMID: 12770934; PubMed Central PMCID: PMC1573843. 100: Berovic M, Habijanic J, Zore I, Wraber B, Hodzar D, Boh B, Pohleven F. Submerged cultivation of Ganoderma lucidum biomass and immunostimulatory effects of fungal polysaccharides. J Biotechnol. 2003 Jun 12;103(1):77-86. PubMed PMID: 12770506. 101: Cao LZ, Lin ZB. Regulatory effect of Ganoderma lucidum polysaccharides on cytotoxic T-lymphocytes induced by dendritic cells in vitro. Acta Pharmacol Sin. 2003 Apr;24(4):321-6. PubMed PMID: 12676071. 102: Zhang HM, Yao WJ, Tian HK. [Effect of lugu Ganoderma lucidum on low-density lipoprotein oxidation and monocyte adhesion to endothelium]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2002 Jul;22(7):534-7. Chinese. PubMed PMID: 12592692. 103: Li P, Zhang K. [Isolation, purification and bioactivities of exopoly saccharides from fermented broth of Ganoderma lucidum]. Wei Sheng Wu Xue Bao. 2000 Apr;40(2):217-20. Chinese. PubMed PMID: 12548949. 104: Hu H, Ahn NS, Yang X, Lee YS, Kang KS. Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF-7 human breast cancer cell. Int J Cancer. 2002 Nov 20;102(3):250-3. PubMed PMID: 12397644. 105: You YH, Lin ZB. Protective effects of Ganoderma lucidum polysaccharides peptide on injury of macrophages induced by reactive oxygen species. Acta Pharmacol Sin. 2002 Sep;23(9):787-91. PubMed PMID: 12230945. 106: Li MC, Liang DS, Xu ZM, Lei LS, Yang SQ. [Effect of Ganoderma polysaccharides on cAMP in murine peritoneal macrophages]. Zhongguo Zhong Yao Za Zhi. 2000 Jan;25(1):41-3. Chinese. PubMed PMID: 12205974. 107: Hsu MJ, Lee SS, Lin WW. Polysaccharide purified from Ganoderma lucidum inhibits spontaneous and Fas-mediated apoptosis in human neutrophils through activation of the phosphatidylinositol 3 kinase/Akt signaling pathway. J Leukoc Biol. 2002 Jul;72(1):207-16. PubMed PMID: 12101282. 108: Cao LZ, Lin ZB. Regulation on maturation and function of dendritic cells by Ganoderma lucidum polysaccharides. Immunol Lett. 2002 Oct 1;83(3):163-9. PubMed PMID: 12095706. 109: Zhang J, Tang Q, Zimmerman-Kordmann M, Reutter W, Fan H. Activation of B lymphocytes by GLIS, a bioactive proteoglycan from Ganoderma lucidum. Life Sci. 2002 Jun 28;71(6):623-38. PubMed PMID: 12072151. 110: Luo J, Zhao YY, Li ZB. A new lanostane-type triterpene from the fruiting bodies of Ganoderma lucidum. J Asian Nat Prod Res. 2002 Jun;4(2):129-34. PubMed PMID: 12067158. 111: Bao XF, Zhen Y, Ruan L, Fang JN. Purification, characterization, and modification of T lymphocyte-stimulating polysaccharide from spores of Ganoderma lucidum. Chem Pharm Bull (Tokyo). 2002 May;50(5):623-9. PubMed PMID: 12036016. 112: Ooi LS, Liu F, Ooi VE, Ng TB, Fung MC. Gene expression of immunomodulatory cytokines induced by Narcissus tazetta lectin in the mouse. Biochem Cell Biol. 2002;80(2):271-7. PubMed PMID: 11989721. 113: Wang YY, Khoo KH, Chen ST, Lin CC, Wong CH, Lin CH. Studies on the immuno-modulating and antitumor activities of Ganoderma lucidum (Reishi) polysaccharides: functional and proteomic analyses of a fucose-containing glycoprotein fraction responsible for the activities. Bioorg Med Chem. 2002 Apr;10(4):1057-62. PubMed PMID: 11836115. 114: Bao XF, Wang XS, Dong Q, Fang JN, Li XY. Structural features of immunologically active polysaccharides from Ganoderma lucidum. Phytochemistry. 2002 Jan;59(2):175-81. PubMed PMID: 11809453. 115: Ma J, Ye Q, Hua Y, Zhang D, Cooper R, Chang MN, Chang JY, Sun HH. New lanostanoids from the mushroom Ganoderma lucidum. J Nat Prod. 2002 Jan;65(1):72-5. PubMed PMID: 11809071. 116: Bao X, Duan J, Fang X, Fang J. Chemical modifications of the (1-->3)-alpha-D-glucan from spores of Ganoderma lucidum and investigation of their physicochemical properties and immunological activity. Carbohydr Res. 2001 Nov 8;336(2):127-40. PubMed PMID: 11689183. 117: Wasser SP, Weis AL. Therapeutic effects of substances occurring in higher Basidiomycetes mushrooms: a modern perspective. Crit Rev Immunol. 1999;19(1):65-96. Review. PubMed PMID: 9987601. 118: Wang SY, Hsu ML, Hsu HC, Tzeng CH, Lee SS, Shiao MS, Ho CK. The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes. Int J Cancer. 1997 Mar 17;70(6):699-705. PubMed PMID: 9096652. 119: van der Hem LG, van der Vliet JA, Kino K, Hoitsma AJ, Tax WJ. Ling-Zhi-8: a fungal protein with immunomodulatory effects. Transplant Proc. 1996 Apr;28(2):958-9. PubMed PMID: 8623480. 120: Chen WC, Hau DM, Wang CC, Lin IH, Lee SS. Effects of Ganoderma lucidum and krestin on subset T-cell in spleen of gamma-irradiated mice. Am J Chin Med. 1995;23(3-4):289-98. PubMed PMID: 8571925. 121: Chen WC, Hau DM, Lee SS. Effects of Ganoderma lucidum and krestin on cellular immunocompetence in gamma-ray-irradiated mice. Am J Chin Med. 1995;23(1):71-80. PubMed PMID: 7598094. 122: van der Hem LG, van der Vliet JA, Bocken CF, Kino K, Hoitsma AJ, Tax WJ. Prolongation of allograft survival with Ling Zhi-8, a new immunosuppressive drug. Transplant Proc. 1994 Apr;26(2):746. PubMed PMID: 8171639. 123: Zhang LX, Mong H, Zhou XB. [Effect of Japanese Ganoderma Lucidum on production of interleukin-2 from murine splenocytes]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1993 Oct;13(10):613-5, 582. Chinese. PubMed PMID: 8312700. 124: Kino K, Sone T, Watanabe J, Yamashita A, Tsuboi H, Miyajima H, Tsunoo H. Immunomodulator, LZ-8, prevents antibody production in mice. Int J Immunopharmacol. 1991;13(8):1109-15. PubMed PMID: 1814848. 125: Kino K, Mizumoto K, Sone T, Yamaji T, Watanabe J, Yamashita A, Yamaoka K, Shimizu K, Ko K, Tsunoo H. An immunomodulating protein, Ling Zhi-8 (LZ-8) prevents insulitis in non-obese diabetic mice. Diabetologia. 1990 Dec;33(12):713-8. PubMed PMID: 2073984. 126: Tasaka K, Mio M, Izushi K, Akagi M, Makino T. Anti-allergic constituents in the culture medium of Ganoderma lucidum. (II). The inhibitory effect of cyclooctasulfur on histamine release. Agents Actions. 1988 Apr;23(3-4):157-60. PubMed PMID: 2455976. 127: Tasaka K, Akagi M, Miyoshi K, Mio M, Makino T. Anti-allergic constituents in the culture medium of Ganoderma lucidum. (I). Inhibitory effect of oleic acid on histamine release. Agents Actions. 1988 Apr;23(3-4):153-6. PubMed PMID: 2455975. 128: Nogami M, Tsuji Y, Kubo M, Takahashi M, Kimura H, Matsuike Y. [Studies on Ganoderma lucidum. VI. Anti-allergic effect. (1)]. Yakugaku Zasshi. 1986 Jul;106(7):594-9. Japanese. PubMed PMID: 2877078. 129: Kohda H, Tokumoto W, Sakamoto K, Fujii M, Hirai Y, Yamasaki K, Komoda Y, Nakamura H, Ishihara S, Uchida M. The biologically active constituents of Ganoderma lucidum (Fr.) Karst. Histamine release-inhibitory triterpenes. Chem Pharm Bull (Tokyo). 1985 Apr;33(4):1367-74. PubMed PMID: 2412714.